Evaluation of Salivary Interleukin-12, Interleukin-23 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma

Abstract Objectives The present study aimed to evaluate interleukin-12 (IL-12) and IL-23 in the saliva of patients with oral lichen planus (OLP) squamous cell carcinoma (SCC). Materials Methods Thirty cases clinical histopathological OLP (bilateral lesions, papular reticular Wickham lines) (Group A), 30 SCCs (OSCCs) B), no history cancer, other or C) were enrolled at Department Oral Medicine School Dentistry, Zahedan, Iran. whole unstimulated was collected salivary concentration IL-12 measured using an enzyme-linked immunosorbent assay laboratory. Statistical Analysis Data analyzed Kruskal–Wallis, Mann–Whitney tests, Pearson's correlation coefficients. Results In study, levels higher OSCC than healthy individuals. Conclusions results show that although cytokines have important role pathogenesis chronic immunity inflammatory diseases, further studies are required assess matrix metalloproteinase links tumor invasion.